Hemolytic Uremic Syndrome
What is hemolytic uremic syndrome (HUS)?HUS is a rare condition that can lead to kidney failure in children. Kidney failure develops as a result of destruction of the small, functional structures and vessels inside the kidney. HUS is a serious illness and potentially fatal. More than 85 percent of patients with the most common form of HUS recover complete kidney function.
What causes hemolytic uremic syndrome?HUS is more common during the summer months and may occur in outbreaks. Outbreaks have been reported in daycare centers, water parks, and fast food restaurants as a result of inadequately cooked hamburger meat.
HUS has several known causes and some unknown causes. Typically in children, HUS develops after an infection with the E. coli bacterium. E. coli may be found in contaminated food such as dairy products and meat. HUS can also develop as a result of taking certain medications or may result from a cancer present in the body, although these causes are less common. Some rare cases of HUS are familial, which suggests a genetic predisposition.
What are the symptoms of hemolytic uremic syndrome?The following are the most common symptoms of HUS. However, each child may experience symptoms differently.
The initial symptoms of HUS frequently last from one to 15 days and may include symptoms in the digestive tract such as the following:
- abdominal pain
- bloody or watery diarrhea
- small, unexplained bruises visible in the lining of the mouth
- pale skin
The body's inability to rid itself of excess fluid and waste may, in turn, cause the following symptoms:
- high blood pressure
- swelling of the hands and feet
- generalized fluid accumulation in the tissues (edema)
How is hemolytic uremic syndrome diagnosed?In addition to a complete medical history and physical examination, diagnostic procedures for hemolytic may include:
- blood tests (to assess blood cell counts, electrolytes, and kidney function)
- urine tests (to check for blood and protein)
- stool tests (to assess for blood)
- abdominal x-ray - a diagnostic test which uses invisible electromagnetic energy beams to produce images of internal tissues, bones, and organs onto film.
Treatment for hemolytic uremic syndrome:Specific treatment for HUS will be determined by your child's physician based on:
- your child's age, overall health, and medical history
- the extent of the condition
- your child's tolerance for specific medications, procedures, or therapies
- expectations for the course of the condition
- your opinion or preference
- intensive care
Close observation and monitoring in an intensive care unit (ICU) may be necessary.
- blood transfusions
Blood transfusions may be necessary to treat moderate to severe cases of anemia (low red blood cell count).
Your child may require intravenous (IV) nutrition if he/she is having severe digestive tract complications.
Dialysis may be required in up to half of all children who develop HUS. Dialysis is a medical procedure to remove wastes and additional fluid from the blood after the kidneys have stopped functioning.
Medications may be required to treat your child's blood pressure, which may be elevated.
Preventing hemolytic uremic syndrome:Completely cooking all foods that may contain hamburger meat can prevent HUS that is caused by E. coli. Other possible sources of E. coli include unpasteurized juices or milk.
If your child has HUS, it is important to notify your daycare center or your child's other close contacts (i.e., play groups, school). HUS is not contagious, but spread of the E. coli bacterium is contagious.
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