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Types of Hematopoietic Stem Cell Transplants |
Syngeneic
Bone marrow from one identical twin to another. Identical twins have
identical genetic types and are a "perfect" match.
Allogeneic
Related -
Marrow from a donor who genetically matches, as close as possible, that of
a patient. This may be a brother or sister, or parent. Siblings have a 1
in 4 chance of being a match. The degree to which the donor's and
patient's tissue match is done by a blood test called HLA typing.
Unrelated (MUD) - Marrow from another person who is not related to the
patient but has similar genetic typing. Through the National Marrow
Donor Program (NMDP) it is possible to find similar matches for patients
that do not have a related donor. The NMDP registry is comprised of
volunteer donors and new donors are added to the list daily. The donors
usually have the marrow harvest within 24 hours of the transplant date
at the transplant center located closest to them. The marrow is sent via
plane with a courier to the patient's BMT center.
Autologous
Patient's own marrow is harvested (removed), purged or treated (if
necessary),and stored (frozen) and re-infused.
Peripheral Stem Cell
Type of transplant in which apheresis is used to collect stem cells from
the blood rather than using bone marrow cells. Apheresis is a process
where blood is removed from the patient via an IV catheter, the stem
cells are selected out by a machine and the remainder of the blood is
returned to the patient. The process takes 3-4 hours/day for 2-5 days
total.
Cord Blood
Stem cells can also be collected from the umbilical cord/placenta
immediately following birth. The cells can be stored (frozen) for
future use. This can be from a sibling or unrelated donor.
Lucile Packard Children's Hospital is located in Palo Alto, adjacent to Stanford University Hospital, approximately 20 miles north of San Jose, CA and 40 miles south of San Francisco.
Lucile Packard Children's Hospital
725 Welch Road
Palo Alto, California 94304
(650) 497-8000
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