Kidney Transplant Program
770 Welch Road, Suite 100
Palo Alto, CA 94304
Monday-Friday, 8:30 am - 5:00 pm
|Phone: (650) 498-5480
Fax: (650) 497-8718
|Learn more about our exciting hospital expansion by visiting growing.lpch.org
Note that during this expansion, routes to 770 Welch have changed.
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Where Care Meets ScienceThe Pediatric Kidney Transplant Program brings together research and clinical care in a single integrated approach. Because the program is a leader in research on kidney disease in children, your child receives the most advanced care available.
Here are some of the areas where LPCH’s Kidney Transplant Program has led the way:
- Transplanting adult-sized kidneys into infants and small children
Transplanting adult-sized kidneys into infants and children, pioneered at LPCH, has achieved the best survival outcomes of any transplanted organ in any age group and set the standard for transplantation success.
- Steroid-free suppression of organ rejection
Used for over 40 years to suppress the immune system and help prevent the body from rejecting transplanted organs, steroids have severe side effects. They can cause high blood pressure, abnormally high blood fat levels, acne, mood swings, diabetes, slow wound healing, soft bones, decreased growth and a puffy appearance. The side effects are particularly significant for infants and small children, in whom the growth-suppressing effects of hormones are often dramatic, and among teenagers, who sometimes skip their medications to avoid side effects like acne and abnormal hair growth and set the stage for chronic organ rejection.
To avoid steroid effects, the Kidney Transplant Program developed a drug program that prevents rejection without steroids. The program has been highly successful, achieving survival rates as high as the standard steroid-based protocol.
Access an abstract of a research article on this innovative approach.
- Genetic profiling
The Kidney Transplant Program is developing ways of determining a child’s inherited likelihood of organ rejection and tailoring post-transplant medications to the patient’s specific genetic profile. This work, while still in its initial stages, promises much more accurate diagnosis of acute rejection of a donated kidney and could improve physicians’ ability to stop the rejection before the kidney is lost.
- Success with very small, very sick newborns
LPCH pioneered the use of dialysis on low birth-weight infants, even those born prematurely, and led the way on successful transplantation in children who are both very young and very small. Much of this success comes from our ability to prepare children for surgery by optimizing dialysis and nutrition and controlling other conditions, such as hypertension. As a result, we have also posted the highest possible success rate — 100% at two years after transplantation — in infants who require both liver and kidney transplantation because of the disease primary hyperoxaluria type I.
Many of these cases come to the Kidney Transplant Program because they pose challenges few other medical centers can meet. These patients include newborns with kidney failure from birth, infants with kidney failure caused by structural abnormalities of the urinary system present at birth, and mothers carrying unborn children with major kidney defects.
In addition, LPCH offers the only cystinosis clinic on the West Coast, as well as the largest such clinic in the country and possibly the world. This rare metabolic disorder causes the amino acid cystine to build to abnormal levels in the body, severely damaging the kidney, eye, thyroid and muscles. Although kidney transplantation forestalls the kidney failure cystinosis can lead to, the disease’s other effects remain. The clinic provides the difficult monitoring necessary to assess the disease and provides needed medications, such as special drops to remove cystine crystals from the eyes.
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- Which Children Need a Kidney Transplant?
- Transplanting Adult Kidneys into Infants and Children
- Frequently Asked Questions (FAQs) about Transplantation
- Research: Areas of Focus
- Ford Family Surgery Center
- The Kidney Transplant Program Team — Who They Are, What They Do
- In the News
- Links and Resources
Julian was born with congenital nephrotic syndrome, an extremely rare and deadly kidney disorder. Julian traveled from his home in Peru to Packard Children's, and a close relative donated a kidney to save his life.
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